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KMID : 0391520150230020031
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Journal of the Korean Child Neurology Society
2015 Volume.23 No. 2 p.31 ~ p.38
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Early Infantile Meningitis Trends in Full-term Infants:A Korean Single-center Study, 2008?20
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Cheon Kyeong-Ryeol
Park Sang-Hyun
Yang Jae-Hyuk
Chung Jae-Keun
Song Eun-Song
Choi Young-Youn
Woo Young-Jong
Kim Young-Ok
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Abstract
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Purpose: The characteristics of early infantile meningitis in full-term and previously healthy infants may differ from those in preterm or previously ill infants. However, full-term and previously healthy infant data remain scarce, and the recent trends
are not well known.
Method: Full-term and previously healthy infants (<3 months old) diagnosed with meningitis in our hospital between January 2008 and December 2013 were enrolled. We retrospectively reviewed their clinical and laboratory data.
Results: A total of 162 full-term and early infants with meningitis (male, 55.6%; mean age, 45 days) were enrolled. Among them, 122 patients (75.3%) were diagnosed with viral meningitis (63 enterovirus-proven and 59 viral-suspected), and 40 patients (24.7%) were diagnosed with bacterial meningitis (18 bacteria-proven and 22 bacterialsuspected). The proportion of early infantile meningitis among all infants admitted (<3 months of age) increased significantly from 1.6% to 3.1%, and viral meningitis increased from 1.1% to 2.3% (P<0.01). Early infantile meningitis increased significantly at each 2-year interval. The seasonal viral meningitis peak shifted from July to June after 2012. Group B Streptococcus was the most common bacterial pathogen (88.9%) and usually caused late-onset meningitis (14 of 16). Coxsackie B viruses were most commonly isolated (59.3%) from the 54 patients with viral meningitis using available genotype data.
Conclusion: Early infantile meningitis in previously healthy full-term infants (<3 months old) increased significantly between 2008 and 2013, and most cases were viral meningitis. The seasonal viral meningitis peak shifted from July to June after 2012.
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KEYWORD
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Meningitis, Term birth, Neonates, Enterovirus, Streptococcus agalactia
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